CV

Education

• M.D. from Icahn School of Medicine at Mount Sinai, 2026
• Ph.D in Immunology, Icahn School of Medicine at Mount Sinai, 2024
• B.S. in Biology, Emory University, 2017
  • Summa Cum Laude, Highest Honors on thesis

Clinical Training

• Resident Physician, Clinical Pathology, Mass General Brigham, 2026-Present
• Clinical Fellow, Harvard Medical School, 2026-Present

Research Experience

• 2019–2024: Ph.D. Researcher at Icahn School of Medicine at Mount Sinai, New York, NY with Advisor: Dr. Faith
  • Demonstrated the gut microbiome’s role in checkpoint blockade–induced colitis
  • Utilized gnotobiotic mouse models and computational analysis of metagenomic and 16S sequencing analysis of patient microbiome data
  • Thesis work resulted in a first-author publication in the Journal of Experimental Medicine
  • Supported by a 5-year F30 NIH fellowship
  • Collaborative projects resulted in co-first (Hepatology Communications), second- (Science Immunology), and third-author (JCI) publications
• 2023–2024: Computational Genomics Trainee
  • Icahn School of Medicine at Mount Sinai, New York, NY
  • Advisor: Dr. Ron Do
  • Developed machine learning–based disease risk models using laboratory values and vitals from the electronic health records of more than 10 million patients
  • Built a robust ETL pipeline for processing and standardizing multi-million-patient datasets for downstream analysis
  • First-author manuscript submitted
• 2016–2017: Honors Thesis Student at Emory University, Atlanta, GA with Advisor: Dr. Cassandra Quave
  • Identified new molecular entities inhibiting Candida albicans growth using herbal extracts, antifungal screening assays, and serial dilution to determine minimum inhibitory concentrations
  • Awarded Highest Honors for thesis
• 2015–2016: Undergraduate Student Researcher at Emory University, Atlanta, GA with Advisor: Dr. Wilfried Rossoll
  • Generated isogenic stem cell lines with CRISPR-Cas9 to model neurodegenerative disease
• Summer 2015: CPRIT-CURE Undergraduate Student Researcher at MD Anderson Cancer Center, Houston, TX with Advisor: Dr. Jae-Il Park
  • Characterized the function of KIAA1211, using CRISPR-Cas9 to generate knockout mice and demonstrate the gene’s role in colorectal cancer
  • Resulted in co-authorship in Nature Cell Biology
• 2014–2015: Undergraduate Student Researcher at Emory University, Atlanta, GA with Advisor: Dr. Lewis
  • Conducted cardiac bioenergetics assays exploring the cardiovascular impact of HIV and methamphetamine, resulting in co-authorship
  • Resulted in co-authorship in Toxicology and applied pharmacology
• Summer 2014: Undergraduate Research Intern at Southern Illinois University, Carbondale, IL with Advisor: Dr. Zhihua Du
  • Conducted structural protein studies via crystallization and molecular biology methods
• 2013–2014: Undergraduate Lab Assistant at Emory University, Atlanta, GA with Advisor: Dr. David Pallas
  • Mouse colony breeding and maintenance, cell culture, genotyping, data collection and analysis

Publications

Baseline colitogenicity and acute perturbations of gut microbiota in immunotherapy-related colitis Permalink

Published in Journal of Experimental Medicine, 2024

Shang, J., Del Valle, D. M., Britton, G. J., Mead, K. R., Rajpal, U., Chen-Liaw, A., Mogno, I., Li, Z., Menon, R., Gonzalez-Kozlova, E., Elkrief, A., Peled, J. U., Gonsalves, T. R., Shah, N. J., Postow, M., Colombel, J.-F., Gnjatic, S., Faleck, D. M., & Faith, J. J. (2024). "Baseline colitogenicity and acute perturbations of gut microbiota in immunotherapy-related colitis." Journal of Experimental Medicine, 222(1), e20232079.

Gastrointestinal germinal center B cell depletion and reduction in IgA+ plasma cells in HIV-1 infection Permalink

Published in Science Immunology, 2024

Cossarini, F., Shang, J., Krek, A., et al. (2024). "Gastrointestinal germinal center B cell depletion and reduction in IgA+ plasma cells in HIV-1 infection." Science Immunology, 9(100), eado0090.

Selective IgA2 deficiency in a patient with small intestinal Crohn's disease Permalink

Published in Journal of Clinical Investigation, 2023

Canales-Herrerias, P., Garcia-Carmona, Y., Shang, J., et al. (2023). "Selective IgA2 deficiency in a patient with small intestinal Crohn's disease." Journal of Clinical Investigation, 133(12), e167742.

SARS-CoV-2 antibody seroconversion in care home Permalink

Published in Nature Reviews Immunology, 2020

Shang, J., & Moreira, A. (2020). "SARS-CoV-2 antibody seroconversion in care home." Nature Reviews Immunology, 20(11), 649.

Human microbial transplant restores T cell cytotoxicity and anti-tumor response to PD-L1 blockade in gnotobiotic mice Permalink

Published in bioRxiv (preprint), 2020

Borgerding, J. N., Shang, J., Britton, G. J., Salmon, H., Bigenwald, C., Maier, B., Rose, S. R., Mogno, I., Kamphorst, A. O., Merad, M., & Faith, J. J. (2020). "Human microbial transplant restores T cell cytotoxicity and anti-tumor response to PD-L1 blockade in gnotobiotic mice." bioRxiv, 2020.08.07.242040.

Immunology of COVID-19: Current State of the Science Permalink

Published in Immunity, 2020

Vabret, N., Britton, G. J., Gruber, C., et al. (2020). "Immunology of COVID-19: Current State of the Science." Immunity, 52(6), 910–941.

Advancing scientific knowledge in times of pandemics Permalink

Published in Nature Reviews Immunology, 2020

Vabret, N., Samstein, R., Fernandez, N., Merad, M., and the Sinai Immunology Review Project (2020). "Advancing scientific knowledge in times of pandemics." Nature Reviews Immunology, 20(6), 338.

Deregulation of CRAD-controlled cytoskeleton initiates mucinous colorectal cancer via β-catenin Permalink

Published in Nature Cell Biology, 2018

Jung, Y. S., Wang, W., Jun, S., Zhang, J., Srivastava, M., Kim, M. J., Lien, E. M., Shang, J., Chen, J., McCrea, P. D., Zhang, S., & Park, J. (2018). "Deregulation of CRAD-controlled cytoskeleton initiates mucinous colorectal cancer via β-catenin." Nature Cell Biology, 20(11), 1303–1314.

Methamphetamine and HIV-Tat alter murine cardiac DNA methylation and gene expression Permalink

Published in Toxicology and Applied Pharmacology, 2015

Koczor, C. A., Fields, E., Jedrzejczak, M. J., Jiao, Z., Ludaway, T., Russ, R., Shang, J., Torres, R. A., & Lewis, W. (2015). "Methamphetamine and HIV-Tat alter murine cardiac DNA methylation and gene expression." Toxicology and Applied Pharmacology, 288(3), 409–419.

Honors and awards

• 2026: Keystone Symposium National Cancer Institute Scholar Award
• 2026: American Association for Cancer Research Scholar-in-Training Award
• 2023: F30 Ruth L. Kirschstein Individual Predoctoral NRSA, NIH (5 years of funding)
• 2023: NIH/NCI Immuno-Oncology Translational Network Early Career Scientist Oral Talk Award
• 2017: Bachelor of Science with Honors, Emory University
• 2017: Darrell Stokes Excellence in Biology Award (Top Biology Graduate)
• 2017: Phi Beta Kappa, Emory University
• 2017: Bobby Jones Scholarship (declined)
• 2016: Barry Goldwater Scholarship, Honorable Mention
• 2016: AACR Top 15 Undergraduate Presenter
• 2016: NIH Advanced Course Scholar, Frontiers in Aging and Regeneration Research
• 2016: Emory Scholars Summer Study Abroad Tuition Award and Supplemental Grant
• 2015: Chris A. Yannopoulos Dean’s Achievement Scholar
• 2015: Emory Scholars Program
• 2015: CPRIT-CURE Summer Research Fellowship, MD Anderson Cancer Center

Oral Presentations

• NCI IOTN Early Career Scientist Award Short Talk, Gaithersburg, MD, 2023
  • “The Role of the Gut Microbiota in Immunotherapy-Related Colitis”
• NCI IOTN Steering Committee Semi-Annual Meetings (virtual), 2022–2023
  • Co-presented microbiome research at an NCI-moderated forum (20-minute talk with Q&A)

Poster presentations

• Keystone Symposium on Cancer Immunotherapy, Quebec, Canada, 2026
  • “The Role of the Gut Microbiota in Immunotherapy-Related Colitis”
• American Association for Cancer Research, Los Angeles, CA, 2026
  • “Bacteroidetes Enrichment Associated with Immune Checkpoint Blockade Resistance and Promote Tumorigenesis in Hepatocellular Carcinoma”
• AAP/ASCI/APSA Joint Meeting, Chicago, IL, 2024
  • “Gut Microbiota in Checkpoint Inhibitor-Induced Colitis Exhibits Baseline Colitogenicity”
• AAP/ASCI/APSA Joint Meeting, Chicago, IL, 2023
  • “Dissecting the Gut Microbiota for Immune Checkpoint Blockade-Resisting Microbes”
• National MD/PhD Conference, Copper Mountain, CO, 2022
  • “Dissecting the Gut Microbiota for Immune Checkpoint Blockade-Resisting Microbes”

Teaching and mentoring

• 2021–2024: Mentor and Lecturer, Medical School Admissions Program (MSAP)
  • Icahn School of Medicine at Mount Sinai
  • Co-developed and delivered the MSAP curriculum supporting master’s students through medical school admissions; led workshops on MCAT preparation, personal statements, interviews, and study strategies, and provided individualized advising resulting in successful matriculations
• 2020–2026: Senior Clinician and Mentor, East Harlem Health Outreach Partnership (EHHOP)
  • Mentored first- and second-year medical students serving as junior clinicians

Skills

• Computational
  • Languages: R, Python, Bash
  • High-performance computing (Minerva)
  • Designed and developed an ETL pipeline processing electronic health records from more than 10 million patients
  • Built an end-to-end microbiome analysis pipeline from raw sequencing files (metagenomics and 16S rRNA) through taxonomic alignment, quality control, and downstream analysis (differential abundance, community composition, alpha and beta diversity, ordination)
  • Machine learning: random forest, EHR-based predictive modeling
• Experimental
  • Murine techniques, including germ-free and gnotobiotic mouse models
  • Anaerobic and aerobic microbial culturing; Bruker Biotyper (MALDI-TOF)
  • PCR, DNA extraction, gel electrophoresis, ELISA
  • Cell culture, tissue fixation

Service and leadership

• 2017–2026: Volunteer Clinician, East Harlem Health Outreach Partnership (EHHOP)
  • Clinic Manager, 2018–2019, coordinating patient services and clinical flow
  • Physician-Scientist Track and senior clinician from 2020, reviewing patient concerns and developing care plans in collaboration with attending physicians
• 2017–2026: MD/PhD Recruitment Participant and Student Admissions Interviewer
  • Icahn School of Medicine at Mount Sinai
  • Interviewer and panelist for prospective MD/PhD candidates; participated in recruitment and second-look events supporting institutional diversity and inclusion efforts
• 2020–2024: Reviewer, Preprint Club
  • Reviewed and critiqued biomedical preprints in a journal-club setting to promote rapid peer feedback during the COVID-19 pandemic; contributed to a Nature Reviews Immunology article